In order to find novel antiviral agents, a series of allosteric MEK1 inhibitors were designed and synthesized.Based on docking results, multiple optimizations were made on the coumarin scaffold.Some of the derivatives showed excellent MEK1 binding affinity in the appropriate enzymatic assays and displayed obvious Balsamo Piedi inhibitory effects on
Glass has a long tradition as a medium for art and sculptural design.Yet, with a few notable exceptions, these items remain small and studio based.Over the last six years, the author has developed a number T-Sak Bags of larger scale projects which bridge the gap between architecture and sculpture.These projects incorporate predominantly annealed gl
Early detection of autism spectrum disorder (ASD) is particularly important given its insidious qualities and the high cost of the diagnostic process.Currently, static functional connectivity studies have achieved significant results in the field of ASD detection.However, with the deepening of clinical research, more and more evidence suggests that